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Is American Airlines safe. Yes, it is considered one of the safest major airlines in the world. The airline adheres to strict safety regulations set by the FAA and other global aviation authorities. It operates a modern, well-maintained fleet and invests heavily in advanced pilot training, emergency preparedness, and regular aircraft inspections. With millions of flights completed each year and a strong safety record, American Airlines continues to prioritize passenger safety at every level. While no form of travel is entirely risk-free, flying with American Airlines is widely regarded as a secure and reliable option for both domestic and international trips.